Physical activity and apoptosis, a brief review of previous findings

Sheikh, Reza; Nikbakht, Masoud

doi:10.22059/sshr.2023.360921.1097

Physical activity and apoptosis, a brief review of previous findings

Document Type : Review Article

Authors

Reza Sheikh ¹
Masoud Nikbakht ²

¹ PhD student in sports physiology, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Ira

² Ph.D. in Sports Physiology, Department of Sports Physiology, Faculty of Sports Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran

10.22059/sshr.2023.360921.1097

Abstract

Background: Physical activity affects the health of the body's organs through several processes. Apoptosis is one of the important cellular processes that play a role in maintaining the balance between cell death and tissue growth.
Aim: The aim of the present study was to examine the previous findings regarding the effect of physical activity and exercise on apoptosis in order to obtain a relatively comprehensive knowledge of this effect by summarizing and analyzing the data.
Materials and Methods: To collect the information of the articles, a search was made from PubMed, MEDLINE, SID, IranMedex, IranDoc, Magiran and Medlib databases. More than 80 scientific articles from 2000 to 2023 were reviewed. The keywords used were: physical activity, aerobic exercise, endurance exercise, apoptosis and cell suicide. After the review, finally 26 articles were selected. Then, the selected items were fully studied and finalized, and the items that were more complete than the others were selected as references.
Conclusion: Physical activity and exercise, especially aerobic exercise, as a safe, cheap and accessible method, can reduce apoptosis through several mechanisms. The breadth of studies in this field, and the overlapping of many data, allows us to confidently introduce exercise and aerobic activity as one of the best methods of regulating body homeostasis and reducing apoptosis.

Keywords

References

[1] Manning AA, Zhao L, Zhu Z, Xiao H, Redington CG, Ding VA, et al. “IL-39 acts as a friend to pancreatic cancer”. Medical Oncology. 2019. 36(1): 1-7. doi: https://doi.org/10.1007/s12032-018-1236-y.

[2] Bremer ZT, Cheragh-Birjandi S, Rezaeian N. “Effect of high-intensity interval training and curcumin supplementation on apoptosis indices TNF-α, nfkb and fas on hippocampal neurotoxicity caused by hydrogen peroxide consumption in male rats”. Applied Health Studies in Exercise Physiology. 2023; 10(2):54-76. doi: 10.22049/JAHSSP.2023.28273.1543.

[3] Rajaei F, Soleimanirad J, Niknafs B, Ghaffari M, Safaeian A. “Effect of vitrification on apoptosis in mouse blastocysts”. Journal of Reproduction & Infertility. 2004; 5(1). 14-22.

[4] Sun Y, Cui D, Zhang Z, Zhang T, Shi J, Jin H, et al. “Attenuated oxidative stress following acute exhaustive swimming exercise was accompanied with modified gene expression profiles of apoptosis in the skeletal muscle of mice”. Oxidative Medicine and Cellular Longevity. 2016; 20(1): 1-9. doi: https://doi.org/10.1155/2016/8381242.

[5] Kordi N, Shafiee N, Mirzaei S, Minavand K, Heidari N. “The effect of continuous and interval cardiac rehabilitation exercise training on tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) in patients with coronary artery bypass graft”. Journal of Isfahan Medical School. 2018; 36(486): 737-742. doi: 10.22122/JIMS.V36I486.10019.

[6] Franzoni F, Federighi G, Fusi J, Cerri E, Banducci R, Petrocchi A, et al. “Physical exercise improves total antioxidant capacity and gene expression in rat hippocampal tissue”. Archives Italiennes de Biologie. 2017; 155(1/2): 1-10. doi: https://doi.org/10.12871/aib.v155i1/2.4604.

[7] Ahmadiasl N, Soufi FG, Alipour M, Bonyadi M, Sheikhzadeh F, Vatankhah A, et al., “Effects of age increment and 36-week exercise training on antioxidant enzymes and apoptosis in rat heart tissue”. Journal of Sports Science & Medicine. 2007; 6(2): 243-249. PMID: 24149335.

[8] Jafari A, Pourrazi H, Nikookheslat S, Baradaran B. “Effect of exercise training on Bcl-2 and bax gene expression in the rat heart”. Gene, Cell and Tissue. 2015; 2(4). 1-6. doi: https://doi.org/10.17795/gct-32833.

[9] Mirdar Harijani S, Musavi N, Hamidian GR. “Effect of endurance swimming training and silymarin treatment on changes in liver apoptotic index in pregnant rats exposed to cadmium”. Journal of Rafsanjan University of Medical Sciences. 2015; 13(8): 705-714. doi: 20.1001.1.17353165.1393.13.8.1.6.

[10] Su SH, Jen CJ, Chen HI. “NO signaling in exercise training-induced anti-apoptotic effects in human neutrophils”. Biochemical and Biophysical Research Communications. 2011; 405(1): 58-63. doi: https://doi.org/10.1016/j.bbrc.2010.12.123.

[11] Seppet E, Orlova E, Seene T, Gellerich FN. “Adaptation of cardiac and skeletal muscle mitochondria to endurance training: implications for cardiac protection”. Cardiac Adaptations: Molecular Mechanisms. 2013; 375-402. doi: https://doi.org/10.1007/978-1-4614-5203-4_20.

[12] Higashi Y, Sukhanov S, Anwar A, Shai SY, Delafontaine P. “Aging, atherosclerosis, and IGF-1”. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2012; 67(6): 626-639. doi: https://doi.org/10.1093/gerona/gls102.

[13] Li CY, Lee JS, Ko YG, Kim JI, Seo JS. “Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation”. Journal of Biological Chemistry. 2000; 275(33): 25665-25671. doi: https://doi.org/10.1074/jbc.M906383199.

[14] Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, et al., “Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome”. Nature Cell Biology. 2000; 2(8): 469-475. doi: https://doi.org/10.1038/35019501.

[15] Ebrahimnezhad N, Nayebifar S, Soltani Z, Khoramipour K. “High-intensity interval training reduced oxidative stress and apoptosis in the hippocampus of male rats with type 2 diabetes: The role of the PGC1α-Keap1-Nrf2 signaling pathway”. Iranian Journal of Basic Medical Sciences. 2023; 26(11): 1-7. doi: 10.22038/IJBMS.2023.70833.15387.

[16] Radak Z, Kumagai S, Nakamoto H, Goto S. “8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats”. Journal of Applied Physiology. 2007; 102(4): 1696-701. doi: https://doi.org/10.1152/japplphysiol.01051.2006.

[17] Quindry J, French J, Hamilton K, Lee Y, Mehta JL, Powers S. “Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals”. Experimental Gerontology. 2005; 40(5): 416-425. doi: https://doi.org/10.1016/j.exger.2005.03.010.

[18] Kavazis AN. “Exercise preconditioning of the myocardium”. Sports Medicine. 2009; 39: 923-935. doi: https://doi.org/10.2165/11317870-000000000-00000.

[19] Cheng SM, Ho TJ, Yang AL, Chen IJ, Kao CL, Wu FN, et al., “Exercise training enhances cardiac IGFI-R/PI3K/Akt and Bcl-2 family associated pro-survival pathways in streptozotocin-induced diabetic rats”. International Journal of Cardiology. 2013; 167(2): 478-485. doi: https://doi.org/10.1016/j.ijcard.2012.01.031.

[20] Huang CY, Yang AL, Lin YM, Wu FN, Lin JA, Chan YS, et al., “Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts”. Journal of Applied Physiology. 2012; 112(5): 883-891. doi: https://doi.org/10.1152/japplphysiol.00605.2011.

[21] Lee SD, Shyu WC, Cheng IS, Kuo CH, Chan YS, Lin YM, et al., “Effects of exercise training on cardiac apoptosis in obese rats”. Nutrition, Metabolism and Cardiovascular Diseases. 2013; 23(6): 566-573. doi: https://doi.org/10.1016/j.numecd.2011.11.002.

[22] Santana ET, Serra AJ, Silva Junior JA, Bocalini DS, Barauna VG, Krieger JE, et al., “Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue”. Motriz: Revista de Educação Física, 2014; 20: 233-238. doi: https://doi.org/10.1590/S1980-65742014000200015.

[23] Hashemi M, Bayat M, Azizi Saraji A, Entezari M. “The effect of swimming exercise on experimental diabetic myopathy in rats”. World J Zool. 2009;4(3):216-22.

[24] Asgharpour-arshad M, Siahkuhian M, Bolboli L, Jafari A, Sheikhzadeh Hesari F. “Effect of three months aerobic interval training on some of mitochondrial apoptotic gene expression in rat skeletal muscle”. Journal of Applied Exercise Physiology. 2017; 13(25): 211-221.

[25] Zhu L, Han MB, Gao Y, Wang H, Dai L, Wen Y, et al., “Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes”. Molecular Medicine Reports. 2015; 12(1): 1151-1156. doi: https://doi.org/10.3892/mmr.2015.3450.

[26] Sandri M, Carraro U, Podhorska-Okolov M, Rizzi C, Arslan P, Monti D, et al., “Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise”. FEBS Letters. 1995; 373(3): 291-295. doi: https://doi.org/10.1016/0014-5793(95)00908-R.

[27] Qiguan J, “The effects of chronic exhaustive training on apoptosis of muscles of rats”. Sport Sci J. 1999; 5(1): 1-6.

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Physical activity and apoptosis, a brief review of previous findings

References

[1] Manning AA, Zhao L, Zhu Z, Xiao H, Redington CG, Ding VA, et al. “IL-39 acts as a friend to pancreatic cancer”. Medical Oncology. 2019. 36(1): 1-7. doi: https://doi.org/10.1007/s12032-018-1236-y.

[3] Rajaei F, Soleimanirad J, Niknafs B, Ghaffari M, Safaeian A. “Effect of vitrification on apoptosis in mouse blastocysts”. Journal of Reproduction & Infertility. 2004; 5(1). 14-22.

[6] Franzoni F, Federighi G, Fusi J, Cerri E, Banducci R, Petrocchi A, et al. “Physical exercise improves total antioxidant capacity and gene expression in rat hippocampal tissue”. Archives Italiennes de Biologie. 2017; 155(1/2): 1-10. doi: https://doi.org/10.12871/aib.v155i1/2.4604.

[7] Ahmadiasl N, Soufi FG, Alipour M, Bonyadi M, Sheikhzadeh F, Vatankhah A, et al., “Effects of age increment and 36-week exercise training on antioxidant enzymes and apoptosis in rat heart tissue”. Journal of Sports Science & Medicine. 2007; 6(2): 243-249. PMID: 24149335.

[8] Jafari A, Pourrazi H, Nikookheslat S, Baradaran B. “Effect of exercise training on Bcl-2 and bax gene expression in the rat heart”. Gene, Cell and Tissue. 2015; 2(4). 1-6. doi: https://doi.org/10.17795/gct-32833.

[9] Mirdar Harijani S, Musavi N, Hamidian GR. “Effect of endurance swimming training and silymarin treatment on changes in liver apoptotic index in pregnant rats exposed to cadmium”. Journal of Rafsanjan University of Medical Sciences. 2015; 13(8): 705-714. doi: 20.1001.1.17353165.1393.13.8.1.6.

[10] Su SH, Jen CJ, Chen HI. “NO signaling in exercise training-induced anti-apoptotic effects in human neutrophils”. Biochemical and Biophysical Research Communications. 2011; 405(1): 58-63. doi: https://doi.org/10.1016/j.bbrc.2010.12.123.

[11] Seppet E, Orlova E, Seene T, Gellerich FN. “Adaptation of cardiac and skeletal muscle mitochondria to endurance training: implications for cardiac protection”. Cardiac Adaptations: Molecular Mechanisms. 2013; 375-402. doi: https://doi.org/10.1007/978-1-4614-5203-4_20.

[12] Higashi Y, Sukhanov S, Anwar A, Shai SY, Delafontaine P. “Aging, atherosclerosis, and IGF-1”. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2012; 67(6): 626-639. doi: https://doi.org/10.1093/gerona/gls102.

[13] Li CY, Lee JS, Ko YG, Kim JI, Seo JS. “Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation”. Journal of Biological Chemistry. 2000; 275(33): 25665-25671. doi: https://doi.org/10.1074/jbc.M906383199.

[14] Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, et al., “Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome”. Nature Cell Biology. 2000; 2(8): 469-475. doi: https://doi.org/10.1038/35019501.

[16] Radak Z, Kumagai S, Nakamoto H, Goto S. “8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats”. Journal of Applied Physiology. 2007; 102(4): 1696-701. doi: https://doi.org/10.1152/japplphysiol.01051.2006.

[17] Quindry J, French J, Hamilton K, Lee Y, Mehta JL, Powers S. “Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals”. Experimental Gerontology. 2005; 40(5): 416-425. doi: https://doi.org/10.1016/j.exger.2005.03.010.

[18] Kavazis AN. “Exercise preconditioning of the myocardium”. Sports Medicine. 2009; 39: 923-935. doi: https://doi.org/10.2165/11317870-000000000-00000.

[20] Huang CY, Yang AL, Lin YM, Wu FN, Lin JA, Chan YS, et al., “Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts”. Journal of Applied Physiology. 2012; 112(5): 883-891. doi: https://doi.org/10.1152/japplphysiol.00605.2011.

[21] Lee SD, Shyu WC, Cheng IS, Kuo CH, Chan YS, Lin YM, et al., “Effects of exercise training on cardiac apoptosis in obese rats”. Nutrition, Metabolism and Cardiovascular Diseases. 2013; 23(6): 566-573. doi: https://doi.org/10.1016/j.numecd.2011.11.002.

[22] Santana ET, Serra AJ, Silva Junior JA, Bocalini DS, Barauna VG, Krieger JE, et al., “Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue”. Motriz: Revista de Educação Física, 2014; 20: 233-238. doi: https://doi.org/10.1590/S1980-65742014000200015.

[23] Hashemi M, Bayat M, Azizi Saraji A, Entezari M. “The effect of swimming exercise on experimental diabetic myopathy in rats”. World J Zool. 2009;4(3):216-22.

[24] Asgharpour-arshad M, Siahkuhian M, Bolboli L, Jafari A, Sheikhzadeh Hesari F. “Effect of three months aerobic interval training on some of mitochondrial apoptotic gene expression in rat skeletal muscle”. Journal of Applied Exercise Physiology. 2017; 13(25): 211-221.

[25] Zhu L, Han MB, Gao Y, Wang H, Dai L, Wen Y, et al., “Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes”. Molecular Medicine Reports. 2015; 12(1): 1151-1156. doi: https://doi.org/10.3892/mmr.2015.3450.

[26] Sandri M, Carraro U, Podhorska-Okolov M, Rizzi C, Arslan P, Monti D, et al., “Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise”. FEBS Letters. 1995; 373(3): 291-295. doi: https://doi.org/10.1016/0014-5793(95)00908-R.

[27] Qiguan J, “The effects of chronic exhaustive training on apoptosis of muscles of rats”. Sport Sci J. 1999; 5(1): 1-6.

Volume 15, Issue 1
January 2023
Pages 137-144

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Physical activity and apoptosis, a brief review of previous findings

References

[1] Manning AA, Zhao L, Zhu Z, Xiao H, Redington CG, Ding VA, et al. “IL-39 acts as a friend to pancreatic cancer”. Medical Oncology. 2019. 36(1): 1-7. doi: https://doi.org/10.1007/s12032-018-1236-y.

[3] Rajaei F, Soleimanirad J, Niknafs B, Ghaffari M, Safaeian A. “Effect of vitrification on apoptosis in mouse blastocysts”. Journal of Reproduction & Infertility. 2004; 5(1). 14-22.

[6] Franzoni F, Federighi G, Fusi J, Cerri E, Banducci R, Petrocchi A, et al. “Physical exercise improves total antioxidant capacity and gene expression in rat hippocampal tissue”. Archives Italiennes de Biologie. 2017; 155(1/2): 1-10. doi: https://doi.org/10.12871/aib.v155i1/2.4604.

[7] Ahmadiasl N, Soufi FG, Alipour M, Bonyadi M, Sheikhzadeh F, Vatankhah A, et al., “Effects of age increment and 36-week exercise training on antioxidant enzymes and apoptosis in rat heart tissue”. Journal of Sports Science & Medicine. 2007; 6(2): 243-249. PMID: 24149335.

[8] Jafari A, Pourrazi H, Nikookheslat S, Baradaran B. “Effect of exercise training on Bcl-2 and bax gene expression in the rat heart”. Gene, Cell and Tissue. 2015; 2(4). 1-6. doi: https://doi.org/10.17795/gct-32833.

[10] Su SH, Jen CJ, Chen HI. “NO signaling in exercise training-induced anti-apoptotic effects in human neutrophils”. Biochemical and Biophysical Research Communications. 2011; 405(1): 58-63. doi: https://doi.org/10.1016/j.bbrc.2010.12.123.

[11] Seppet E, Orlova E, Seene T, Gellerich FN. “Adaptation of cardiac and skeletal muscle mitochondria to endurance training: implications for cardiac protection”. Cardiac Adaptations: Molecular Mechanisms. 2013; 375-402. doi: https://doi.org/10.1007/978-1-4614-5203-4_20.

[12] Higashi Y, Sukhanov S, Anwar A, Shai SY, Delafontaine P. “Aging, atherosclerosis, and IGF-1”. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences. 2012; 67(6): 626-639. doi: https://doi.org/10.1093/gerona/gls102.

[13] Li CY, Lee JS, Ko YG, Kim JI, Seo JS. “Heat shock protein 70 inhibits apoptosis downstream of cytochrome c release and upstream of caspase-3 activation”. Journal of Biological Chemistry. 2000; 275(33): 25665-25671. doi: https://doi.org/10.1074/jbc.M906383199.

[14] Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, et al., “Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome”. Nature Cell Biology. 2000; 2(8): 469-475. doi: https://doi.org/10.1038/35019501.

[16] Radak Z, Kumagai S, Nakamoto H, Goto S. “8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats”. Journal of Applied Physiology. 2007; 102(4): 1696-701. doi: https://doi.org/10.1152/japplphysiol.01051.2006.

[17] Quindry J, French J, Hamilton K, Lee Y, Mehta JL, Powers S. “Exercise training provides cardioprotection against ischemia-reperfusion induced apoptosis in young and old animals”. Experimental Gerontology. 2005; 40(5): 416-425. doi: https://doi.org/10.1016/j.exger.2005.03.010.

[18] Kavazis AN. “Exercise preconditioning of the myocardium”. Sports Medicine. 2009; 39: 923-935. doi: https://doi.org/10.2165/11317870-000000000-00000.

[20] Huang CY, Yang AL, Lin YM, Wu FN, Lin JA, Chan YS, et al., “Anti-apoptotic and pro-survival effects of exercise training on hypertensive hearts”. Journal of Applied Physiology. 2012; 112(5): 883-891. doi: https://doi.org/10.1152/japplphysiol.00605.2011.

[21] Lee SD, Shyu WC, Cheng IS, Kuo CH, Chan YS, Lin YM, et al., “Effects of exercise training on cardiac apoptosis in obese rats”. Nutrition, Metabolism and Cardiovascular Diseases. 2013; 23(6): 566-573. doi: https://doi.org/10.1016/j.numecd.2011.11.002.

[22] Santana ET, Serra AJ, Silva Junior JA, Bocalini DS, Barauna VG, Krieger JE, et al., “Aerobic exercise training induces an anti-apoptotic milieu in myocardial tissue”. Motriz: Revista de Educação Física, 2014; 20: 233-238. doi: https://doi.org/10.1590/S1980-65742014000200015.

[23] Hashemi M, Bayat M, Azizi Saraji A, Entezari M. “The effect of swimming exercise on experimental diabetic myopathy in rats”. World J Zool. 2009;4(3):216-22.

[24] Asgharpour-arshad M, Siahkuhian M, Bolboli L, Jafari A, Sheikhzadeh Hesari F. “Effect of three months aerobic interval training on some of mitochondrial apoptotic gene expression in rat skeletal muscle”. Journal of Applied Exercise Physiology. 2017; 13(25): 211-221.

[25] Zhu L, Han MB, Gao Y, Wang H, Dai L, Wen Y, et al., “Curcumin triggers apoptosis via upregulation of Bax/Bcl-2 ratio and caspase activation in SW872 human adipocytes”. Molecular Medicine Reports. 2015; 12(1): 1151-1156. doi: https://doi.org/10.3892/mmr.2015.3450.

[26] Sandri M, Carraro U, Podhorska-Okolov M, Rizzi C, Arslan P, Monti D, et al., “Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise”. FEBS Letters. 1995; 373(3): 291-295. doi: https://doi.org/10.1016/0014-5793(95)00908-R.

[27] Qiguan J, “The effects of chronic exhaustive training on apoptosis of muscles of rats”. Sport Sci J. 1999; 5(1): 1-6.

Volume 15, Issue 1January 2023Pages 137-144

Files

Share

How to cite

Statistics

Volume 15, Issue 1
January 2023
Pages 137-144