The Effect of Eight weeks of Quercetin Supplementation and Intermittent Exercise on Gene Expression of Muc5Ac, Muc4 and Polyphosphate in Rats with Colon Cancer.

Document Type : Research Paper

Authors

1 Master of sport sciences, Imam Khomeini International University, Qazvin, Iran.

2 20 Noroozian

3 Imam Khomeini International University

Abstract

Abstract
background: expression of mucosal genes would affect the function of internal organs of the body and the digestive system, such as by creating a blockage for the progression of cancerous tumors and the failure of the target tissue, especially the large intestine.
Method: 24 rats were randomly assigned into four groups including quercetin (n=6), exercise (n=6), quercetin+ exercise and control group. colon cancer induction was provided with the use of 1,2-dimethylhydrazine for 10 weeks and daily quercetin supplementation of 50 mg/kg body weight of mice by Gavagene method. exercise protocol was performed 5 sessions per week with intensity of 60-70%, maximum speed of 23 m/min with 2-minute rest in eight weeks. ANOVA was used to analyze data. The level of significance was set at alpha p < .05.
Results: a significant difference was found in the positive gene expression of Muc5Ac and Muc4 in the four groups (p<0.05). Furthermore, a negative significant difference was observed in polyphosphate level of the four groups (p<0.05).
Conclusion: It was concluded that Intermittent exercise and quercetin supplementation would increase the expression of Muc5Ac and Muc4 genes in the large intestine of mice with colon cancer.

Keywords

Sport Sciences and Health Research
Volume 15, Issue 1
January 2023

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