The role of aerobic training with the Vaccinium Arctostaphylos L. fruit hydro-alcoholic extract in the regulation of oxidative stress in the heart tissue of diabetic rats

Document Type : Research Paper

Authors

1 Assistant Professor, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran.

2 Ph.D. student, Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tabriz, Tabriz, Iran

3 Associate Professor in Comparative Histology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Abstract

Background: Cardiovascular disease is a significant contributor to mortality in diabetic patients. Despite the potential benefits of concomitant and complementary training in diabetic patients, there is a paucity of evidence in this area.
Aim: The objective of this study was to investigate the effect of aerobic training in conjunction with a hydroalcoholic extract of the fruit of Qaraqat on superoxide dismutase, glutathione peroxidase, total antioxidant capacity, and malondialdehyde in the heart tissue of male rats with type 2 diabetes.
Materials and Methods: 24 male rats aged 8 weeks were diabetic with a high-fat diet (60%) and streptozotocin injection. They were randomly divided into four groups: (1) aerobic training (AT), (2) supplementation (Sup), (3) Aerobic training+ supplement (AT+Sup), and (4) diabetes control (Con). The training protocol included running on a treadmill at a speed of 5-24 m/min for 10-60 min, according to the principle of overload. Glucose, insulin, insulin resistance, and MDA, TAC, GPX, and SOD of heart tissue were measured. Statistical tests of two-way variance and post hoc Bonferroni were used using SPSS software at a significance level of P<0.005.
Results A significant decrease in glucose levels, insulin resistance, and MDA (P<0.005) was observed in the intervention groups following eight weeks of training and supplement intervention, in comparison to the Con group. Also, the amount of insulin in Sup and AT+Sup groups exhibited a notable decline in comparison to Con and AT groups (P<0.005), as well as a substantial increase in the levels of SOD (P=0.001) and GPx (P<0.005), and TAC (P<0.005) was observed.
Conclusion: Diabetes is associated with elevated MDA levels, which are reduced by aerobic training and supplementation. Furthermore, the administration of a training intervention and the utilization of a supplement have been demonstrated to elevate the levels of SOD, TAC, and GPx.

Keywords

References

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Sport Sciences and Health Research
Volume 16, Issue 1
January 2024
Pages 115-128

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