The effect of male body mass index (BMI) on COVID- 19 disease infection

Document Type : Research Paper


M.Sc. Department of Pathology and Corrective Movements, Faculty of PhysicalEducation and Sports Sciences, University of Isfahan, Isfahan, Iran.


Background: Since the outbreak of COVID-19 virus and the rise in concerns, researchers have been investigating risk factors of this disease. One of the factors affecting the hospitalization of influenza patients is high BMI. Due to the relation between COVID-19 disease and influenza.
Aim: the purpose of this study was to investigate the effect of BMI on the infection and severity of COVID-19 patients.
Materials and Methods: BMI of 126 men was calculated and three groups of "appropriate weight", "overweight" and "obese" were identified. Then, the prevalence and severity of their disease were recorded. For data analysis, chi2 test was used in SPSS 26 software at a significance level of P= 0.05.
Results: Prevalence of COVID-19 infection in the group with “appropriate weight”, ”overweight” and “fat” were 56%, 61% and 58%, respectively. Mild infection was reported in the three groups, 27%, 27% and 26%, respectively; Moderate infection was 22%, 26% and 26%, respectively; and severe infection was 7%, 8% and 5%, respectively. Therefore, there was no significant difference between their infection and the severity of infection in groups (P˃.05).
Conclusion: Obesity has negative effect on the body's immune response and lung function. The hospitalization rate for influenza is higher in this group. But in infection of COVID-19 and severity of this disease, no significant difference was observed between men with different BMI. However, due to the relation between obesity, cardiovascular disease, diabetes, and the vulnerability of these patients to the COVID-19 virus, serious attention is necessary to prevent these individuals from COVID-19.


[1] Karasek Jr RA. “Job demands, job decision latitude, and mental strain: Implications for job redesign”. Adm Sci. 1979; 24(2): 285-308.
[2] Vaishya R. “COVID-19 pandemic and the Olympic Games”. Journal of Clinical Orthopedics and Trauma. 2020; 11: 281-292.
[3] Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, Xiang J, Wang Y, Song B, Gu X, et al. “Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study”. Lancet. 2020; 395: 1054-1062. Doi: 10.1016/S0140-6736(20)30566-3.
[4] Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, Liu XQ, Chen RC, Tang CL, Wang T, et al. “Comorbidity and its impact on 1590 patients with COVID-19 in China: A nationwide analysis”. Eur. Respir. J. 2020; 55(1): 1-56. .
[5] Mehra MR, Desai SS, Kuy S, Henry TD, Patel AN. “Cardiovascular disease, drug therapy, and mortality in Covid-19”. N. Engl. J. Med. 2020; 382(25): e102. Doi: 10.1056/nejmoa2007621.
[6] Louie JK, Acosta M, Winter K, Jean C, Gavali S, Schechter R, Vugia DJ, Harriman K, Matyas B, Glaser CA, et al. “Factors associated with death or hospitalization due to pandemic 2009 influenzam A (H1N1) infection in California”. JAMA. 2009; 302(17): 1896. Doi: 10.1001/jama.2009.1583.
[7] Moser JA, Galindo-Fraga A, Ortiz-Hernández AA, Gu W, Hunsberger S, Galán-Herrera JF, Guerrero ML, Ruiz-Palacios GM, Beigel JH, Magaña-Aquino M. “Underweight, overweight, and obesity as independent risk factors for hospitalization in adults and children from influenza and other respiratory viruses”. Influ. Other Respir. Viruses. 2018; 13: 3-9. Doi: 10.1111/irv.12618.
[8] Hu X, Pan X, Zhou W, Gu X, Shen F, Yang B, Hu Z. “Clinical epidemiological analyses of overweight/obesity and abnormal liver function contributing to prolonged hospitalization in patients infected with COVID-19”. Int. J. Obes. 2020; 44(8): 1784-1789. Doi: 10.1038/s41366-020-0634-3.
[9] Zhang F, Xiong Y, Wei Y, Hu Y, Wang F, Li G, Liu K, Du R, Wang C, Zhu W. “Obesity predisposes to the risk of higher mortality in young COVID-19 patients”. J. Med. Virol. 2020; 29(11): 2536-2542. Doi: 10.1002/jmv.26039.
[10] Prevention CfDCa. People at high risk for flu complications. 2018; Available online: (accessed on 19 March 2020).
[11] Harris J, Perumalswami CR, Langa KM, Wright AA, Griggs JJ. “The relationship of obesity to hospice use and expenditures”. Ann. Intern. Med. 2017; 166(6): 3810389. Doi: 10.7326/M16-0749.
[12] Hajifathalian K, Kumar S, Newberry C, Shah S, Fortune B, Krisko T, Ortiz-Pujols S, Zhou XK, Dannenberg AJ, Kumar R, et al. “Obesity is associated with worse outcomes in COVID-19: analysis of early data from New York City”. Obesity. 2020; 28(9): 1606-1612. Doi: 10.1002/oby.22923.
[13] Argenziano MG, Bruce SL, Slater CL, Tiao JR, Baldwin MR, Barr RG, Chang BP, Chau KH, Choi JJ, Gavin N, et al. “Characterization and clinical course of 1000 Patients with COVID-19 in New York: Retrospective case series”. med Rxiv. 2020; 369(March). Doi: 10.1136/bmj.m1996.
[14] Kass DA, Duggal P, Cingolani O. “Obesity could shift severe COVID-19 disease to younger ages”. Lancet. 2020; 395: 1544-1545. Doi: 10.1016/S0140-6736(20)31024-2.
[15] Bhasin A, Nam H, Yeh C, Lee J, Liebovitz D, Achenbach C. “Is BMI higher in younger patients with COVID-19? Association between BMI and COVID-19 hospitalization by age”. Obesity. 2020; 28(10): 1811-1814. Doi: 10.1002/oby.22947.
[16] Ong SWX, Young BE, Leo YS, Lye DC. “Association of higher body mass index (BMI) with severe coronavirus disease 2019 (COVID-19) in younger patients”. Clin. Infect. Dis. 2020; 71(16): 2300-2032. Doi: 10.1093/cid/ciaa548.
[17] Zachariah P, Johnson CL, Halabi KC, Ahn D, Sen AI, Fischer A, Banker SL, Giordano M, Manice CS, Diamond R, et al. “Epidemiology, clinical features, and disease severity in patients with coronavirus disease 2019 (COVID-19) in a children’s hospital in New York City, New York. JAMA Pediatr. 2020; 174(10): 1-7. Doi: 10.1001/jamapediatrics.2020.2430.
[18] Ellulu MS, Ismail P, Khaza’Ai H, Rahmat A, Abed Y. “Obesity and inflammation: The linking mechanism and the complications”. Arch. Med Sci. 2017; 13: 851-863.
[19] Andersen C, Murphy KE, Fernandez ML. “Impact of obesity and metabolic syndrome on immunity. Adv. Nutr. 2016; 7: 66-75.