The Effect of Aerobic Exercise on Mitochondrial Dynamics in the Muscle Tissue of Diabetic Rats

Document Type : Research Paper

Authors

1 Department of Physical Education, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

2 Masters student, Department of Physical Education, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

10.22059/sshr.2025.382235.1164

Abstract

the aim of this research was to study the effect of eight weeks of aerobic exercise on proteins levels of MFN1, MFN2, FIS1 and Drp1 in Gastrocnemius muscle of diabetic rats. the 20 male Wistar rats were randomly divided into four groups of DC, DT, HC and HT. Induction of diabetes was done by High-Fat Diet and Streptozotocin. the aerobic training program was carried out for eight weeks based on the principle of gradual overload. 48 hours after the last training session the Gastrocnemius muscle was extracted. The levels of proteins were evaluated by western blot. One-way ANOVA analysis with Tukey's post hoc was used for comparison of variables in between groups.
Induced diabetes led to a significant decrease in MFN1 (P=0.001) and MFN2 (P=0.019) and a significant increase in FIS1(P=0.012) and Drp1(P=0.023) in the diabetic rats. However, aerobic exercise led to a significant increase in MFN1(P=0.009) and MFN2 (P=0.015) and a significant decrease in FIS1(P=0.002) and Drp1(P=0.034) proteins in the muscle of diabetic rats (P< 0.05).
exercise as a beneficial and without complications strategy has a essential role to maintenance the balance of mitochondrial dynamics and its optimal function in the diabetic skeletal muscles.

Keywords

Files

Share

How to cite

Statistics